Simon Wittekind was born in Bad Kissingen on December 10, 1892 as the son of the Kissingen merchant Wilhelm Wittekind and his wife Fanny, née Mendle. He lived with his parents at Marktplatz 4. From 1902 till 1909, he attended Kissingen Realschule and changed to Oberrealschule Würzburg after finishing middle school. There he graduated with his Abitur in 1913. For the winter semester of 1913/14, he enrolled for studying medicine at Universität Munich which he continued in Würzburg when the war began. But after the beginning of the war, he was drafted as a soldier and became a medical officer. In the winter semester of 1916/17, he was given time off to do his “Physikum” (intermediate exam for students of medicine). Afterwards he served in the war till its end. After the end of the war, he returned to his hometown for a short time and then stayed shortly in Heidelberg, Frankfort, Munich and Würzburg. In Würzburg where he continued his studies, he passed his state exam in 1920 and was promoted Doctor of Medicine in 1921.

Simon Wittekind joined the student association “Abituria Wirceburgia”, one of the few associations that didn’t exclude their Jewish members in the Era of National Socialism.

After a short stay in Munich, he returned to his parents to Promenadestrasse 5 in March 1922 before he moved to Berlin in June 1924 and practiced as a general practitioner in Berlin-Weißensee till 1934. In June 1929, Simon Wittekind had married Anna Wolff from Frankfort. Her two children A(ha)ron and Jakob (Baruch) were born in Berlin.

Together with his brother Max Dr. Simon Wittekind and his family fled from Nazi terror to Palestine in 1935 or 1936, where he practiced as a doctor in Haifa in 1936. Simon Wittekind emigrated from there to South Africa a few years later. His wife Anna stayed with the children in Israel because she felt safer there and probably also because her father and her two brothers lived in Palestine. Simon and Anna Wittekind divorced soon afterwards, and Anna married Herbert Feige from Hildesheim in 1948. The two sons from her marriage to Simon Wittekind took the surname Yardeni in Palestine. Simon Wittekind lost his German citizenship and his doctor title was withdrawn by Universität Würzburg in 1940. His brother Max and his mother Fanny could also emigrate to Johannesburg. 

Dr. Simon Wittekind was a doctor at Oribi Military Hospital in Pietermaritzburg in South Africa in 1942 as can be deduced from the obituary for his mother Fanny of that year. He is listed – different from his siblings – as “Captain Dr. Simon Wittekind” without a wife being mentioned. Later - probably in the mid-1960s - he returned to Germany and spent the last years of his life in Würzburg, where he died in November 1969 at the age of 76.